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Ketamine is a very powerful anesthetic that can cause serious harm. Taking ketamine can be fatal, particularly if it is mixed with other drugs. Ketamine can increase your heart rate and blood pressure. It can make you confused, agitated, delirious and disconnected from reality. It can make you feel sick, and it can cause damage to your short- and long-term memory. Because of the body’s loss of feelings, paralysis of the muscles and the mind’s loss of touch with reality, you can be left vulnerable to hurting yourself or being hurt by others. Because you don’t feel pain properly when you’ve recently taken ketamine, you can injure yourself and not know you’ve done it. Ketamine can cause serious bladder problems, with the urgent and frequent need to pee. This can be very painful and the pee can be blood-stained. Although stopping using ketamine can help, sometimes the damage can be so serious that the bladder needs surgical repair or even removal. The urinary tract, from the kidneys down to the bladder, can also be affected and incontinence (uncontrolled peeing) may also developed. Abdominal pain, sometimes called ‘K cramps’, have been reported by people who have taken ketamine for a long time. Evidence of liver damage due to regular, heavy ketamine use is emerging. The liver has a range of important functions, such as cleaning your blood and removing toxic substances.